| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | B-cell lymphoma/leukemia 11B;BCL-11B;B-cell CLL/lymphoma 11B;COUP-TF-interacting protein 2;Radiation-induced tumor suppressor gene 1 protein;hRit1;BCL11B;CTIP2, RIT1; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Form | Liquid |
| Host | |
| Immunogen | A synthesized peptide derived from human Ctip2 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Storage | |
| Target | |
| UniProt # |
Overview
This product is an anti-BCL11B antibody for target detection and characterization. Key identifiers include host species: Rabbit; Monoclonal; clone AODC-2; isotype Rabbit IgG; reactivity: Human. Reported application contexts include WB (as provided in the source record). Boster Bio Anti-Ctip2 Rabbit Monoclonal Antibody catalog # M01485. Tested in WB application. This antibody reacts with Human.
Key elements and design rationale
- Target: BCL11B (B-cell lymphoma/leukemia 11B).
- Antibody format: Monoclonal; clone AODC-2; isotype Rabbit IgG.
- Host: Rabbit.
- Species reactivity: Human (confirm in your model system with appropriate controls).
This description is intended to help interpret the antibody design and the biological context of the target using the fields provided in the catalog record, alongside general experimental considerations.
Biological background
BCL11B (protein: Glycogen synthase kinase-3 beta (gsk3b)) is a commonly studied target in molecular and cellular biology. Functional context (as provided): Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through , TFCOUP2-independent binding to a GC-rich response element (By similarity). . Reported cellular localization context: Nucleus . Tissue expression notes (as provided): Highly expressed in brain and in malignant T- cell lines derived from patients with adult T-cell leukemia/lymphoma.
Research relevance and current trends
- Research context keywords from the source record include: Acetylation,Cancer,Cancer Susceptibility,Chromatin Binding Proteins,Chromatin Modifying Enzymes,Class I,DNA/RNA Binding,Domain Families,Epigenetics and Nuclear Signaling,Neural Signal Transduction,Neurogenesis,Neurology Process,Neuroscience,Oncoproteins/Suppressors,p53 Pathway,Transcription,Transcription Factors,Tumor Suppressors,Zinc Finger.
- Current studies often focus on connecting target abundance/localization to pathway perturbations across models, tissues, and cell states.
- Quantitative and multiplexed assays (e.g., imaging + immunoblot panels) are commonly used to compare phenotypes across conditions and time-courses.
Common research applications
- Western blotting (WB): assess relative target abundance across samples, treatments, or time-points.
Workflow ideas (metafield): Validate BCL11B antibody specificity using KO/KD control samples (WB/IF/IHC as appropriate), Detect BCL11B expression by Western blot in cell or tissue lysates, Compare relative BCL11B levels across experimental conditions (dose/time-course) using antibody-based readouts
Notes for experimental interpretation
- Consider isoforms and post-translational modifications (PTMs) that may shift apparent molecular weight or epitope accessibility.
- Apparent molecular weight may vary by sample type and processing (observed MW: 59 kDa; calculated MW: 95519 MW).
- Control concepts: include appropriate negative controls (e.g., isotype, KO/KD samples) and orthogonal validation when feasible.
Additional product details (from the source record)
- Molecular weight (observed): 59 kDa
- Cellular localization (provided): Nucleus .
- Tissue details (provided): Highly expressed in brain and in malignant T- cell lines derived from patients with adult T-cell leukemia/lymphoma.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
