| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Forkhead box protein P2;CAG repeat protein 44;Trinucleotide repeat-containing gene 10 protein;FOXP2;CAGH44, TNRC10; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | E. coli-derived human FOXP2 recombinant protein (Position: L637-E715). Human FOXP2 shares 100% amino acid (aa) sequence identity with both mouse and rat FOXP2. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
This antibody is intended for detection of FOXP2 (Protein NDRG1) in biological samples using common immunoassay formats. It is typically selected based on target identity, species reactivity, clonality/clone information, and detection modality.
Vendor notes: Boster Bio Anti-FOXP2 Antibody Picoband® catalog # A01329-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key elements and design rationale
- Antibody format: Rabbit Polyclonal Rabbit IgG
- Immunogen / epitope context: E. coli-derived human FOXP2 recombinant protein (Position: L637-E715). Human FOXP2 shares 100% amino acid (aa) sequence identity with both mouse and rat FOXP2. (reported region: L637-E715).
- Molecular weight context: reported MW: 90 kDa; calculated MW: 79919 MW
- Reactivity: Human,Mouse,Rat
- Applications: WB
As a polyclonal antibody, the reagent recognizes multiple epitopes on the target, which can improve detection robustness but may increase sensitivity to sample-dependent epitope changes.
Biological background
Protein NDRG1; Forkhead box protein P2. Forkhead box protein P2 (FOXP2) is a protein that, in humans, is encoded by the FOXP2 gene. This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind ly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Functional note: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language. Reported localization: Nucleus . Expression/tissue context: Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. .
Research relevance and current trends
- Epigenetics and Nuclear Signaling: Researchers commonly examine how FOXP2 (Protein NDRG1) relates to this theme using model systems and orthogonal readouts.
- Forkhead Box: Researchers commonly examine how FOXP2 (Protein NDRG1) relates to this theme using model systems and orthogonal readouts.
- Transcription: Researchers commonly examine how FOXP2 (Protein NDRG1) relates to this theme using model systems and orthogonal readouts.
Common research applications
- Western blotting: compare relative FOXP2 (Protein NDRG1) levels across conditions; band patterns may reflect isoforms and processing.
Notes for experimental interpretation
- Specificity notes: No cross reactivity with other proteins.
- Cross-reactivity: No cross-reactivity with other proteins.
- Isoforms and PTMs: Apparent size and signal patterns can differ across splice isoforms, proteolytic processing, and post-translational modifications.
- Controls: Include an isotype control (as relevant), no-primary control for imaging, and orthogonal validation such as KD/KO samples when available.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
