| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Major prion protein;PrP;ASCR;PrP27-30;PrP33-35C;CD230;PRNP;ALTPRP, PRIP, PRP; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | A synthesized peptide derived from human GSTO1 |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Boster Bio Anti-GSTO1 Rabbit Monoclonal Antibody catalog # M02461-1. Tested in WB, ICC/IF applications. This antibody reacts with Human.
Protein: T-cell surface glycoprotein CD3 zeta chain | Gene: Major prion protein | Target: GSTO1 | Function: May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu (2+) or ZN (2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity). . | Research areas: Hematopoietic Progenitors,Neurodegenerative Disease,Neurology Process,Neuroscience,Stem Cells,Surface Molecules
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 27G30 | Isotype: IgG | Reactivity: Human | Immunogen: A synthesized peptide derived from human GSTO1 | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB, IF, ICC
Observed MW: 28 kDa | Calculated MW: 27661 MW
Cellular localization: Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of CU (2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis.
Tissue details: Ubiquitous.
Status: Active
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
