Anti-IL23 Receptor/IL23R Antibody Picoband®

Overview

Anti-IL23 Receptor/IL23R Antibody Picoband® is an antibody for IL23R detection raised in Rabbit (Polyclonal, Rabbit IgG), with reported reactivity: Human. Commonly used in WB, IHC, Flow Cytometry, ELISA workflows.

Key elements and design rationale

• Target: IL23R (interleukin 23 receptor); UniProt: Q5VWK5
• Antibody format: Rabbit, Polyclonal, Rabbit IgG
• Molecular weight: 72 kDa
• Applications: WB, IHC, Flow Cytometry, ELISA

Vendor description (summary): Boster Bio Anti-IL23 Receptor/IL23R Antibody Picoband® catalog # A00607-3.

Biological background

Biological context: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity). .

Expression and localization notes: cellular localization: Cell membrane ; Single-pass type I membrane protein ., tissue context: Expressed by Th1, Th2 and dendritic cells..

Common research applications

• Western blotting (WB): Compare IL23R levels across samples and conditions using appropriate loading and biological controls.
• Immunohistochemistry (IHC): Evaluate spatial distribution of IL23R in tissue sections, considering fixation and antigen retrieval effects.
• Flow cytometry: Quantify IL23R-positive populations in single-cell suspensions with appropriate gating and controls.
• ELISA: Use antibody-based detection formats to assess antigen presence or binding in plate-based assays.

Notes for experimental interpretation

• Account for isoforms, post-translational modifications, and sample-specific processing that can shift apparent molecular weight or epitope accessibility.
• Use positive/negative biological controls where possible (e.g., known-expressing cells/tissues, knockdown/knockout models) and include appropriate secondary-only/isotype controls for imaging workflows.

Additional product notes (from provided fields)

• Background: Interleukin 23 receptor is a type I cytokine receptor. IL23R is its human gene. The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
• Cross reactivity: No cross-reactivity with other proteins.
• Cellular localization: Cell membrane ; Single-pass type I membrane protein .
• Tissue details: Expressed by Th1, Th2 and dendritic cells.
• Research category: Cell Type Markers,Cytokines,Epigenetics and Nuclear Signaling,Immunoglobulins,Immunology,Innate Immunity,Interleukins,Nuclear Signaling,Nuclear Signaling Pathways,Receptors,Signal Transduction,Signaling Pathway

Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.