| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Forkhead box protein O3;AF6q21 protein;Forkhead in rhabdomyosarcoma-like 1;FOXO3;FKHRL1, FOXO3A; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | A synthesized peptide derived from human Phospho-Chk2 (T68) |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Target | |
| UniProt # |
Boster Bio Anti-Phospho-Chk2 (T68) Rabbit Monoclonal Antibody catalog # P00277-1. Tested in WB, IP applications. This antibody reacts with Human.
Gene: Forkhead box protein O3 | Target: CHEK2 | Function: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. . | Research areas: Apoptosis,Associated Proteins,Cancer,Cell Biology,Co-Activators/Co-Repressors,Domain Families,Epigenetics and Nuclear Signaling,Forkhead Box,Hypoxia,Intracellular,Metabolism,Metabolism Processes,Nuclear Receptors,Nuclear Signaling Pathways,Oncoproteins,Oncoproteins/Suppressors,Pathways and Processes,Transcription,Transcription Factors
Host: Rabbit | Clonality/Clone: Monoclonal / Clone: 27C74 | Isotype: IgG | Reactivity: Human | Immunogen: A synthesized peptide derived from human Phospho-Chk2 (T68) | Concentration: 0.5mg/ml | Purification: Affinity-chromatography
Applications: WB, IP
Observed MW: 62 kDa | Calculated MW: 71277 MW
Cellular localization: Cytoplasm, cytosol. Nucleus. Translocates to the nucleus upon oxidative stress and in the absence of survival factors.
Tissue details: Ubiquitous. .
Phospho site(s): T68
Status: Active
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