| Field | Specification |
|---|---|
| Mfr No | |
| Accession Number | |
| Alternative Names | Solute Carrier Family 38 Member 2, Sodium-Coupled Neutral Amino Acid Transporter 2, System A Amino Acid Transporter 2, System N Amino Acid Transporter 2, SAT2 |
| Clonality | |
| Conjugate | |
| Host | |
| Isotype | |
| Product Type | |
| Reactivity | |
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| Target |
Overview
Anti-SLC38A2 (SNAT2) Antibody is an antibody targeting Solute Carrier Family 38 Member 2, Sodium-Coupled Neutral Amino Acid Transporter 2, System A Amino Acid Transporter 2, System N Amino Acid Transporter 2, SAT2 Polyclonal raised in Rabbit (Unconjugated). This antibody is commonly used in IHC, WB to detect, localize, or compare expression of the target across samples.
Key elements and design rationale
- Target: Solute Carrier Family 38 Member 2, Sodium-Coupled Neutral Amino Acid Transporter 2, System A Amino Acid Transporter 2, System N Amino Acid Transporter 2, SAT2 (also reported as Solute Carrier Family 38 Member 2, Sodium-Coupled Neutral Amino Acid Transporter 2, System A Amino Acid Transporter 2, System N Amino Acid Transporter 2, SAT2).
- Immunogen/epitope region: Intracellular, N-terminus..
- Homology note: Human, rat- identical (informative for cross-species interpretation).
- Species reactivity (as provided): Human, Rat, Mouse.
- Lot quality control (as provided): Western blot analysis.
- Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry.
- Blocking peptide: Available for antigen preadsorption control where appropriate.
- Conjugate/format: Unconjugated (may affect detection channel and background).
These attributes help researchers interpret whether signal reflects the intended target in a given assay and sample context.
Biological background
Solute carrier family 38 member 2, SLC38A2, also known as sodium-coupled neutral amino acid symporter 2, system A amino acid transporter 2 (ATA2), and system N amino acid transporter 2 (SNAT2), is a cotransporting symporter of neutral amino acids and sodium ions across the cell membrane with a 1:1 stoichiometry.1,2The mechanism of transport of SLC38A2 is pH-sensitive, Na+ dependent, Li+-intolerant, and exhibits specificity for short-chain neutral amino acids. SLC38A2 is composed of 506 amino acids and possesses 11 transmembrane domains with an intracellular N terminus and an extracellular C-terminus, as indicated by hydropathy analysis. Competition experiments demonstrate that human SLC38A2 recognizes multiple neutral amino acids as substrates, including alanine, glycine, serine, proline, methionine, asparagine, glutamine, threonine, and leucine.
Research relevance and current trends
- Linking transporter/channel abundance to ionic homeostasis and excitability-related phenotypes.
- Studying compartment-specific localization (surface vs intracellular pools) and trafficking dynamics.
- Combining antibody readouts with functional assays for more complete interpretation.
Common research applications
- Western blot (WB): compare target abundance/size across lysates and conditions; consider isoforms/PTMs.
- Immunohistochemistry (IHC): examine spatial distribution in tissue and relate signal to cell-type composition.
Interpretation typically benefits from comparing matched sample sets (e.g., treated vs control, WT vs KO/KD) and using orthogonal readouts where feasible.
Notes for experimental interpretation
- Isoforms and post-translational modifications can shift apparent molecular weight or epitope accessibility across samples.
- Cross-species signal may depend on epitope conservation; consult the provided homology note when selecting models.
- Permeabilization, fixation, and antigen retrieval can change accessibility of intracellular vs extracellular epitopes.
- Conceptual control: antigen preadsorption (blocking peptide) can help assess signal dependence on the immunogen region.
- Provided control suggestions: Negative control: BLP-NT185.
- Application notes: see product-specific dilution/usage notes and control concepts provided in the dataset.
Application abbreviations: CBE- Cell-based ELISA, FC- Flow cytometry, ICC- Immunocytochemistry, IE- Indirect ELISA, IF- Immunofluorescence, IFC- Indirect flow cytometry, IHC- Immunohistochemistry, IP- Immunoprecipitation, LCI- Live cell imaging, N- Neutralization, WB- Western blot. Species abbreviations: H- Human, M- Mouse, R- Rat.
Recommended controls: Blocking peptide: BLP-NT185; Negative control: BLP-NT185.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
