| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Protein Tnn ;Tnn ; |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Gene ID | |
| Host | |
| Immunogen | Human tenascin. |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Reconstitution | |
| Target | |
| UniProt # |
Overview
Anti-Tenascin TNN Antibody (Monoclonal, BC-24) is an antibody targeting TNN. Common applications include WB, IHC, ICC. Key specifications include host: Mouse; clonality: Monoclonal; clone: Clone: BC-24; isotype: Mouse IgG1; reactivity: Human; observed MW: 272 kDa; calculated MW: 173250 MW.
Boster Bio Anti-Tenascin TNN Antibody (Monoclonal, BC-24) catalog # MA1094. Tested in IHC, ICC, WB applications. This antibody reacts with Human.
Key elements and design rationale
- Target: TNN — tenascin N
- Antibody format: Host: Mouse; Clonality: Monoclonal; Clone: Clone: BC-24; Isotype: Mouse IgG1
- Species reactivity: Human
- Molecular weight guidance: Observed: 272 kDa; Calculated: 173250 MW
Specificity note: No cross reactivity with other proteins.
Biological background
Protein function (datasheet): TNN: Involved in neurite outgrowth and cell migration inhippocampal explants.
Scientific background (datasheet): The tenascins are a family of extracellular matrix proteins (ECMs). Tenascin is an extracellular matrix protein. It expressed in an unusually restricted pattern during embryogenesis and has been implicated in a variety of morphogenetic phenomena. Human hexabrachion gene (tenascin) is mapped to chromosome 9, bands q32-q34. The coding region of the hexabrachion gene spans approximately 80 kilobases of DNA and consists of 27 exons separated by 26 introns.
Cellular localization (datasheet): TNN: Secreted, extracellular space, extracellularmatrix.|Tnn: Secreted, extracellular space, extracellularmatrix.
Tissue details (datasheet): Expressed in neurons. The larger forms (isoform tau-A and isoform tau-B) are preferentially expressed in the peripheral nervous system while the other are expressed in the central nervous system. Low amounts of the larger forms are also found in limited areas of the CNS.
Sequence similarities (datasheet): Belongs to the tenascin family.
Research relevance and current trends
- Commonly studied in contexts related to Actin, etc.,Cardiovascular,Contractility,Cytoskeleton,Cytoskeleton/ECM,Microfilaments,Signal Transduction.
- Supports comparative expression analysis across conditions, genotypes, or treatments when paired with appropriate controls.
- Useful for confirming target presence and subcellular distribution using orthogonal readouts (e.g., microscopy vs. immunoblotting).
Common research applications
- Western blot (WB): Compare relative target abundance and apparent size/isoforms across samples; interpret bands in light of expected MW and potential PTMs.
- Immunohistochemistry (IHC): Assess tissue distribution and cell-type patterns; interpret staining with appropriate negative controls and antigen context.
- Immunofluorescence / ICC: Visualize subcellular localization and co-localization patterns; consider fixation/permeabilization compatibility and controls.
Notes for experimental interpretation
- Consider isoforms, post-translational modifications, and processing that can shift apparent molecular weight or localization.
- Cross-reactivity (datasheet): No cross-reactivity with other proteins
- Use appropriate positive and negative controls (e.g., KO/KD, blocking peptide, or isotype controls) to support specificity interpretation.
As a monoclonal antibody, this reagent is expected to recognize a defined epitope, which can support consistency across lots when epitope accessibility is preserved.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
