| Field | Specification |
|---|---|
| Gene ID | |
| UniProt # | |
| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Applications | |
| Conjugate | |
| Concentration | |
| Storage | |
| Storage buffer | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
CD11b is a 170 kD glycoprotein also known as αM integrin, Mac-1 α subunit, Mol, CR3, and Ly-40. CD11b is a member of the integrin family, primarily expressed on granulocytes, monocytes/macrophages, dendritic cells, NK cells, and subsets of T and B cells. CD11b non-covalently associates with CD18 (β2 integrin) to form Mac-1. Mac-1 plays an important role in cell-cell interaction by binding its ligands ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), iC3b, and fibrinogen.
Validated Applications & Recommended Dilutions
| Application | Recommended Dilution |
|---|---|
| Flow Cytometry | See product datasheet |
Antibody Specifications
| Target | CD11b |
|---|---|
| Host Species | Rat |
| Clonality | Monoclonal |
| Isotype | Rat IgG2b, κ |
| Conjugate | APC |
| Clone Number | M1/70 |
| Purification | See datasheet |
| Concentration | 5 μL/Test |
Immunogen
Recombinant protein fragment; see full datasheet. UniProt: P05555;P11215.
Species Reactivity & Cross-Reactivity
Validated for: Human, Mouse. Verify suitability in your sample type prior to use. For species or applications not listed in the datasheet, consult our technical team before purchase.
Storage & Handling
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Storage Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Related Products
Browse additional antibodies targeting CD11b and complementary reagents — including secondary antibodies, blocking buffers, and detection kits — available through BioHippo.
This antibody is validated for flow cytometry applications. For intracellular targets, fix and permeabilize cells using a validated fixation/permeabilization kit (e.g., BD Cytofix/Cytoperm or similar) before staining. For surface markers, stain live or fixed cells without permeabilization. Always include a matched isotype control (Rat IgG2b, κ, Rat origin) at the same protein concentration as the test antibody to establish non-specific binding thresholds. Recommended starting dilution/concentration: see datasheet.
This antibody has been experimentally validated in: Human, Mouse. Cross-reactivity with other species has not been systematically evaluated. If your sample species is not listed, assess immunogen sequence homology to your target species ortholog. The immunogen used is: "" — higher sequence identity between species increases the probability of cross-reactivity, but experimental validation with appropriate controls is necessary before drawing scientific conclusions.
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. Storage Buffer: Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.. To maintain antibody activity, avoid repeated freeze-thaw cycles. Aliquot into single-use volumes before first freeze. If working with the antibody frequently, keep a working stock at 4°C for up to 4 weeks — add 0.02% sodium azide to the working stock as a bacteriostatic agent if azide is not already present in the buffer. Monitor performance against a validated positive control when transitioning between storage aliquots or lots.
This monoclonal antibody (clone M1/70) provides highly consistent, epitope-specific recognition of CD11b, making it ideal for quantitative assays, multiplex panels, and studies requiring strict reproducibility across experiments and independent laboratories. Unlike polyclonal preparations, each production batch from a single hybridoma clone generates antibody with identical epitope specificity, affinity, and isotype — ensuring reliable signal comparison in longitudinal studies or multi-site collaborations. When citing this antibody in publications, include the clone designation (clone M1/70) to enable third-party reproducibility verification.
Customization & Add-ons: Can't find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
A Dual Drug-Loaded Smart Liposome System Capable of Capturing Leukemia Cells Followed by Releasing Drugs Within Cells for Synergistic Therapy (2025) ADVANCED FUNCTIONAL MATERIALS. 10.1002/adfm.202425739
Photosynthetic Plant-Derived Nanovesicles Precisely Amplify Photodynamic Effect by Light-Activated Oxygen Generation for Enhanced Cancer Photoimmunotherapy (2025) ACS Nano. 10.1021/acsnano.5c13350
Intranasal blood-brain barrier bypass enables sequential mitochondria-targeted bioengineered nanolamellar system for ischemic stroke therapy (2026) Nature Communications. 10.1038/s41467-025-68024-5
The self-adjuvant heterocyclic lipid nanoparticles encapsulated with vaccine and STAT3 siRNA boost cancer immunotherapy through DLN-targeted and STING pathway (2023) CHEMICAL ENGINEERING JOURNAL. 10.1016/j.cej.2023.146474
Cancer Cell-Intrinsic Cholesterol Induces Lipid-Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression (2026) Advanced Science. 10.1002/advs.202508588
TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6–GAS6 Axis (2026) Advanced Science. 10.1002/advs.202520739
Sonofoam: An ultrasound-responsive foam for broad pleural coverage and sonoporation-enhanced drug delivery in pleurodesis (2026) CHEMICAL ENGINEERING JOURNAL. 10.1016/j.cej.2026.173517
Charge-Reversal Nanoassembly for Rheumatoid Arthritis Therapy via Cell-Free DNA Scavenging and Microenvironment Reprogramming (2025) BIOMATERIALS. 10.1016/j.biomaterials.2025.123591
Arginine-assembly as NO nano-donor prevents the negative feedback of macrophage repolarization by mitochondrial dysfunction for cancer immunotherapy (2024) BIOMATERIALS. 10.1016/j.biomaterials.2024.122474
Dual-action ROS-responsive nanoparticles for synergistic suppression of pyroptosis and cfDNA in inflammatory bowel diseases (2026) JOURNAL OF CONTROLLED RELEASE. 10.1016/j.jconrel.2026.114928
Bionic gene delivery system activates tumor autophagy and immunosuppressive niche to sensitize anti-PD-1 treatment against STK11-mutated lung adenocarcinoma (2025) JOURNAL OF NANOBIOTECHNOLOGY. 10.1186/s12951-025-03404-z
Lactiplantibacillus plantarum -derived extracellular vesicles alleviate acute lung injury by inhibiting ferroptosis of macrophages (2025) JOURNAL OF NANOBIOTECHNOLOGY. 10.1186/s12951-025-03405-y
Biomimetic sequentially gated nanotuners based on amorphous metal–organic frameworks for reprogramming the metabolism-ferroptosis-immunity crosstalk in gliomas (2026) Materials Today Bio. 10.1016/j.mtbio.2026.102973
Protective role of the novel cytokine Metrnl/ interleukin-41 in host immunity defense during sepsis by promoting macrophage recruitment and modulating Treg/Th17 immune cell balance (2023) CLINICAL IMMUNOLOGY. 10.1016/j.clim.2023.109690
Ly6G+ Neutrophils and Interleukin-17 Are Essential in Protection against Rodent Malaria Caused by Plasmodium berghei ANKA (2024) Research. 10.34133/research.0559
Adipocyte-specific FAK deletion promotes pancreatic β-cell apoptosis via adipose inflammatory response to exacerbate diabetes mellitus (2024) Clinical and Translational Medicine. 10.1002/ctm2.1742
Autophagy is essential for human myelopoiesis. (2024) Stem Cell Reports. 10.1016/j.stemcr.2023.12.005
Apolipoprotein E deficiency potentiates macrophage against Staphylococcus aureus in mice with osteomyelitis via regulating cholesterol metabolism (2023) Frontiers in Cellular and Infection Microbiology. 10.3389/fcimb.2023.1187543
Combining Lactate Oxidase and Metformin in Cancer Cell Membrane-Biomimetic Liposomes for Synergistic Ferroptosis Induction and Hypoxia-Alleviated Cancer Therapy (2026) COLLOIDS AND SURFACES B-BIOINTERFACES. 10.1016/j.colsurfb.2026.115420
NEDD4 like E3 ubiquitin protein ligase-mediated ubiquitination and degradation of dipeptidyl peptidase 4 restrains Th2-linked inflammation in allergic rhinitis (2026) BIOCHEMICAL PHARMACOLOGY. 10.1016/j.bcp.2026.117960
Oroxylin a promoted apoptotic extracellular vesicles transfer of glycolytic kinases to remodel immune microenvironment in hepatocellular carcinoma model (2023) EUROPEAN JOURNAL OF PHARMACOLOGY. 10.1016/j.ejphar.2023.176037
Macrophage Membrane-Cloaked ROS-Responsive Albumin Nanoplatforms for Targeted Delivery of Curcumin to Alleviate Acute Liver Injury (2025) MOLECULAR PHARMACEUTICS. 10.1021/acs.molpharmaceut.4c00808
ADAM8 Destroys the Endothelial Barrier and Promotes Leukocyte Extravasation to Aggravate Hepatic Ischemia–Reperfusion Injury (2025) FASEB JOURNAL. 10.1096/fj.202500697R
Monocyte Transmigration Involves in Remifentanil Induced Mechanical Hyperalgesia in Animal Models and a Randomized Controlled Clinical Trial (2026) Journal of Pain Research. 10.2147/JPR.S545720
Ajania purpurea Extract Attenuates LPS-Induced Inflammation in RAW264.7 Cells and Peritonitis Mice (2022) BIOLOGICAL & PHARMACEUTICAL BULLETIN. 10.1248/bpb.b22-00388
