Bafilomycin A1

Bafilomycin A1 is a macrolide antibiotic that selectively inhibits vacuolar-type H⁺-ATPases (V-ATPases), disrupting lysosomal acidification and autophagic flux. In neuroscience, Bafilomycin A1 is widely used to study autophagy, a critical process for neuronal health and protein clearance. By blocking autophagosome-lysosome fusion or lysosomal degradation, Bafilomycin A1 allows researchers to assess autophagic activity and flux in neuronal cells. Impaired autophagy is a common feature in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS. Bafilomycin A1 is instrumental in elucidating the role of lysosomal dysfunction in these conditions and in evaluating therapeutic strategies aimed at restoring autophagic balance.

Classification: D2B- Toxic Material Causing Other Toxic Effects Irritant

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H315- Causes skin irritation.
• H319- Causes serious eye irritation.
• H335- May cause respiratory irritation.

Precautionary statements:

• P261- Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
• P264- Wash skin thoroughly after handling.
• P271- Use only outdoors or in a well-ventilated area.
• P280- Wear protective gloves/ eye protection/ face protection.
• P302 + P352- IF ON SKIN: Wash with plenty of soap and water.
• P304 + P340- IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for
• breathing.
• P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312- Call a POISON CENTER or doctor/ physician if you feel unwell.
• P321- Specific treatment (see supplemental first aid instructions on this label).
• P332 + P313- If skin irritation occurs: Get medical advice/ attention.
• P337 + P313- If eye irritation persists: Get medical advice/ attention.
• P362- Take off contaminated clothing and wash before reuse.
• P403 + P233- Store in a well-ventilated place. Keep container tightly closed.
• P405- Store locked up.
• P501- Dispose of contents/ container to an approved waste disposal plant.

Bafilomycin A1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-391)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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