| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile, INCB028050, LY3009104 |
| Cas No. | |
| Form | White to off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (30 mg/ml); or DMF (50 mg/ml) |
| Source | Synthetic |
| Storage |
Baricitinib is a selective Janus kinase (JAK1/JAK2) inhibitor that modulates immune signaling by suppressing cytokine release. While primarily used in autoimmune diseases and COVID-19-related cytokine storm management, Baricitinib is gaining interest in neuroinflammation research.
Chronic activation of JAK-STAT signaling is implicated in neurodegenerative diseases such as multiple sclerosis and Alzheimer’s. By dampening pro-inflammatory cytokine cascades, Baricitinib may offer neuroprotective benefits and is being explored as a therapeutic candidate for CNS disorders involving immune dysregulation and glial activation.
Details:
Hazard statements
Harmful if swallowed.
· Precautionary statements
Wash thoroughly after handling.
Do not eat, drink or smoke when using this product.
Baricitinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-587)
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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