| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione; NSC-26326 |
| Cas No. | |
| Form | Orange powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (35 mg/ml); or Ethanol (15 mg/ml) |
| Source | Synthetic |
| Storage |
β-Lapachone is a naturally derived quinone with potent anti-cancer and redox-modulating properties. It selectively targets cells overexpressing NAD(P)H:quinone oxidoreductase 1 (NQO1), leading to reactive oxygen species (ROS) generation and apoptosis.
In neuroscience, β-Lapachone has shown promise in reducing cognitive impairment and neuroinflammation in amyloid-induced models. Its ability to modulate oxidative stress and suppress NF-κB activation positions it as a potential neuroprotective agent in Alzheimer’s disease and other oxidative stress-related neurodegenerative conditions.
Details:
May be harmful by inhalation, ingestion, or skin absorption. May cause eye, skin, or respiratory system irritation.
Beta-Lapachone (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-589)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. SM Wuerzberger et al. Cancer Res. 1998 58:1876
3. JJ Pink et al. J. Biol. Chem. 2000 275:5416
4. D Siegel et al. Biochem. Pharmacol. 2012 83:1033
5. GZ Dong et al. Exp. Mol. Med. 2010 42:327
