| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | N-Benzyl-3,5-dicarbethoxy-4-phenyl-1,4-dihydropyridine |
| Form | Off-White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 5 mg/ml DMSO |
| Source | Synthetic |
| Storage |
BML-278 is a selective, cell-permeable activator of SIRT1, a NAD⁺-dependent deacetylase involved in regulating cellular stress responses, metabolism, and aging. With high specificity for SIRT1 over SIRT2 and SIRT3, BML-278 enhances SIRT1 activity at low micromolar concentrations. In neuroscience, SIRT1 activation is associated with neuroprotection, improved mitochondrial function, and reduced neuroinflammation. SIRT1 modulates key transcription factors such as PGC-1α and FOXO, which are involved in oxidative stress resistance and neuronal survival. BML-278 is increasingly used in models of Alzheimer’s and Parkinson’s disease to investigate therapeutic strategies targeting age-related cognitive decline and neurodegenerative mechanisms.
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Bml-278 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-349)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
