Cantharidin

Cantharidin is a naturally occurring toxin that inhibits protein phosphatases PP1 and PP2A, enzymes involved in a wide range of cellular processes including signal transduction, cell cycle regulation, and apoptosis. In neurodegenerative disease research, Cantharidin is used to study phosphatase-mediated regulation of tau phosphorylation and neuronal integrity. Its ability to disrupt phosphatase activity makes it a useful probe for investigating the molecular underpinnings of neurodegeneration and synaptic dysfunction.

Classification: Acute toxicity, Oral (Category 2), H300

Skin irritation (Category 2), H315

Eye irritation (Category 2A), H319

Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H300 Fatal if swallowed.
• H315 Causes skin irritation.
• H319 Causes serious eye irritation.
• H335 May cause respiratory irritation.

Precautionary statements:

• P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
• P264 Wash skin thoroughly after handling.
• P270 Do not eat, drink or smoke when using this product.
• P271 Use only outdoors or in a well-ventilated area.
• P280 Wear protective gloves/ eye protection/ face protection.
• P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
• P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
• P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
• P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
• P321 Specific treatment (see supplemental first aid instructions on this label).
• P330 Rinse mouth.
• P332 + P313 If skin irritation occurs: Get medical advice/ attention.
• P337 + P313 If eye irritation persists: Get medical advice/ attention.
• P362 Take off contaminated clothing and wash before reuse.
• P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
• P405 Store locked up.
• P501 Dispose of contents/ containerto an approved waste disposal plant.

Cantharidin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-519)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).