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| Immunogen | A synthesized peptide derived from human PCTAIRE1 was used as the immunogen for the CDK16 antibody. |
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Overview
CDK16 Antibody / PCTK1 / PCTAIRE1 is a anti-CDK16 Rabbit antibody Recombinant Rabbit Monoclonal clone 29C70 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: CDK16
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 29C70, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
CDK16 antibody is widely used in neuroscience and reproductive biology research. In neurons, CDK16 regulates exocytosis of synaptic vesicles, contributing to neurotransmitter release and synaptic plasticity. In germ cells, CDK16 supports spermatogenesis by modulating vesicular transport and cytoskeletal organization. Mutations or altered expression of CDK16 have been linked to intellectual disability, developmental delay, and reproductive disorders. By detecting CDK16, researchers can study how kinase signaling influences both neuronal communication and fertility.
The antibody is validated for western blotting, immunohistochemistry, immunofluorescence, and ELISA. In western blot assays, CDK16 antibody detects bands corresponding to expected isoforms, enabling quantitative comparisons across tissues. Immunohistochemistry demonstrates tissue localization in brain and testis, while immunofluorescence highlights cytoplasmic distribution in neurons and germ cells. ELISA applications allow measurement of CDK16 protein levels in experimental samples.
Beyond physiology, CDK16 has been implicated in cancer. Elevated expression has been reported in breast, lung, and prostate carcinoma, where it contributes to proliferation, survival, and invasion. CDK16 modulates signaling pathways that intersect with tumor suppressor networks, suggesting its role as a driver of oncogenesis. By applying CDK16 antibody, scientists can evaluate how kinase dysregulation promotes tumor development and whether CDK16 serves as a therapeutic target or biomarker.
CDK16 also participates in insulin secretion, immune responses, and cellular differentiation. Its broad influence highlights the importance of studying this kinase in diverse biological contexts. In experimental systems, CDK16 interacts with proteins that regulate exocytosis and endocytosis, linking it to fundamental processes of intracellular trafficking. This versatility makes CDK16 antibody a valuable reagent for both basic and translational research.
CDK16 antibody offered by
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
