| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human delta 2 Catenin was used as the immunogen for the CTNND2 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
CTNND2 Antibody / Delta 2 Catenin is a anti-CTNND2 Rabbit antibody Recombinant Rabbit Monoclonal clone 31C89 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) with listed reactivity in Mouse, Rat.
Key elements and design rationale
- Target: CTNND2
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 31C89, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB, ICC, IF
Biological background
CTNND2 antibody is widely applied in neuroscience, developmental biology, and cancer research. In neurons, delta 2 catenin links cadherins to cytoskeletal networks, stabilizing synaptic contacts and influencing learning and memory. CTNND2 mutations are associated with intellectual disability, autism spectrum disorder, and Alzheimer disease. By detecting CTNND2, researchers can investigate how adhesion and signaling complexes shape neuronal connectivity and cognition.
Applications of CTNND2 antibody include western blotting, immunohistochemistry, and immunofluorescence. Western blot assays detect CTNND2 protein in neuronal lysates, immunohistochemistry maps expression in brain regions such as hippocampus and cortex, and immunofluorescence highlights localization at dendritic spines. These assays provide strong tools for evaluating CTNND2 in neural development and disease.
Beyond neuroscience, CTNND2 is implicated in cancer biology. Delta 2 catenin expression has been reported in prostate, lung, and colorectal cancers, where it modulates Wnt signaling and epithelial mesenchymal transition. By applying CTNND2 antibody, scientists can study how altered adhesion and signaling contribute to tumor progression. The protein's dual role in adhesion and transcriptional regulation makes it relevant across fields.
CTNND2 interacts with cadherins, beta catenin, and small GTPases, integrating adhesion complexes with cytoskeletal remodeling. Loss of CTNND2 disrupts synaptic stability, while overexpression promotes abnormal signaling. These mechanisms underline its importance in both development and disease. Antibody based detection enables detailed analysis of these molecular interactions.
Therapeutically, CTNND2 is a candidate biomarker for neurodevelopmental disorders and certain cancers. Its role in synaptic function and adhesion highlights potential as a diagnostic marker. CTNND2 antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunofluorescence: visualize subcellular distribution and cell-to-cell heterogeneity.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
