| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human CXCR6 / CD186 was used as the immunogen for the CXCR6 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
CXCR6 Antibody / C-X-C chemokine receptor type 6 / CD186 is a anti-CXCR6 Rabbit antibody Recombinant Rabbit Monoclonal clone 31C52 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.
Key elements and design rationale
- Target: CXCR6
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 31C52, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
CXCR6 antibody is widely applied in immunology, oncology, and infectious disease research. In immunity, CXCR6 guides tissue resident memory T cells and NKT cells to inflamed sites, supporting pathogen defense and tissue homeostasis. In cancer, CXCR6 expression is associated with tumor infiltrating lymphocytes and modulation of the tumor microenvironment. By detecting CXCR6, researchers can study how chemokine receptors regulate immunity and disease progression.
Flow cytometry distinguishes CXCR6 positive lymphocyte subsets in blood and tissues. Immunohistochemistry maps expression in liver, lung, and tumors, while immunofluorescence highlights surface localization on immune cells. These applications provide versatile tools for studying chemokine receptor biology.
CXCR6 also plays roles in viral infection and chronic inflammation. It serves as a co-receptor for HIV entry into cells and contributes to pathogenesis of liver disease. By applying CXCR6 antibody, scientists can investigate receptor function in immune surveillance, infection, and cancer immunity.
CXCR6 antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
