| Field | Specification |
|---|---|
| Alternative names | (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,3 1-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, Cyclosporin A |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C62H111N11O12 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble to 100 mM in DMSO, 50 mM in ethanol |
| SMILES | |
| InChIKey | |
| Form | White Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Cyclosporine A is a cyclic peptide immunosuppressant that inhibits calcineurin, thereby preventing the activation of NF-AT and downstream T-cell responses. In neuroscience, cyclosporine has been investigated for its neuroprotective effects, particularly in models of traumatic brain injury, stroke, and neurodegenerative diseases. By inhibiting mitochondrial permeability transition pore (mPTP) opening, cyclosporine helps preserve mitochondrial integrity and prevent apoptosis in neurons. Its ability to modulate calcium signaling and reduce oxidative stress makes it a promising agent for protecting neural tissue under pathological conditions.
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
- R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
- R45 - May cause cancer
- R62 - Possible risk of impaired fertility
- R68 - Possible risk of irreversible effects
Hazard Phrases:
H302-H350-H360
Precautionary Phrases:
P201-P308 + P313
Cyclosporine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-201)
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2. Ganong W.F. Review of Medical Physiology, 22nd edition. Lange Medical Books, Chapter 27, Page 530.
