Cyclosporine

Cyclosporine A is a cyclic peptide immunosuppressant that inhibits calcineurin, thereby preventing the activation of NF-AT and downstream T-cell responses. In neuroscience, cyclosporine has been investigated for its neuroprotective effects, particularly in models of traumatic brain injury, stroke, and neurodegenerative diseases. By inhibiting mitochondrial permeability transition pore (mPTP) opening, cyclosporine helps preserve mitochondrial integrity and prevent apoptosis in neurons. Its ability to modulate calcium signaling and reduce oxidative stress makes it a promising agent for protecting neural tissue under pathological conditions.

Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.

Safety Phrases:

• S22 - Do not breathe dust
• S24/25 - Avoid contact with skin and eyes
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)

Risk Phrases:

• R20/21/22 - Harmful by inhilation, in contact with skin and if swallowed
• R45 - May cause cancer
• R62 - Possible risk of impaired fertility
• R68 - Possible risk of irreversible effects

Hazard Phrases:

H302-H350-H360

Precautionary Phrases:

P201-P308 + P313

Cyclosporine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-201)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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