| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | DMOG, N-(Methoxyoxoacetyl)-glycine methyl ester |
| Cas No. | |
| Form | Off-white solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (>25 mg/ml), 100% ethanol (>25 mg/ml) or dimethyl formamide, or PBS pH7.2 (10 mg/ml) |
| Source | Synthetic |
| Storage |
DMOG is a cell-permeable inhibitor of prolyl-4-hydroxylase and factor inhibiting HIF (FIH), leading to stabilization and activation of hypoxia-inducible factor (HIF). In neuroscience, DMOG is used to model hypoxic conditions and to study HIF-mediated neuroprotection, angiogenesis, and metabolic adaptation. HIF activation has been linked to enhanced neuronal survival, reduced oxidative stress, and improved vascularization—mechanisms relevant to stroke, traumatic brain injury, and neurodegenerative diseases. DMOG’s ability to upregulate HIF signaling in vivo and attenuate ischemic injury makes it a powerful compound for investigating therapeutic strategies targeting brain hypoxia and mitochondrial dysfunction. Its pro-angiogenic properties also support research into neurovascular remodeling and blood-brain barrier integrity.
Classification: Caution. Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25 - Avoid contact with skin and eyes
Hazard Statements:
H302 - Harmful if swallowed
Dimethyloxaloylglycine (DMOG) (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-382)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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2. Mai A., et al. (2005) J. Med. Chem. 48(24): 7789-95.
3. Kahyo T., et al. (2008) J. Pharmacol. Sci. 108(3): 364-71.
4. Jung-Hynes B., et al. (2009) J. Biol. Chem. 284(6): 3823-32.
