| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone |
| Cas No. | |
| Form | Crystalline solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO |
| Source | Synthetic |
| Storage |
Dovitinib is a multi-targeted receptor tyrosine kinase inhibitor with activity against FLT-3, c-KIT, VEGFR, PDGFRβ, and CSF-1R. While primarily investigated for its anti-cancer properties, Dovitinib's inhibition of VEGFR and PDGFRβ has implications for neurovascular health and neuroinflammation. These pathways are increasingly recognized in the pathophysiology of neurodegenerative diseases, including Alzheimer's and Parkinson's. By modulating angiogenic and inflammatory signaling, Dovitinib may offer neuroprotective benefits and serve as a tool for studying neurovascular dysfunction in disease models.
Classification: Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 2
Target Organ Systemic Toxicity (single exposure), Category 3
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
H335:
May cause respiratory irritation.
Precautionary statements:
- P302+352: IF ON SKIN: Wash with plenty of soap and water.
- P332+313: If skin irritation occurs, get medical advice/attention.
- P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P337+313: If eye irritation persists, get medical advice/attention.
- P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312:
Call a {POISON CENTER/doctor/...} if you feel unwell.
Dovitinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-500)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
