| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Eicosanoyl serotonin; Eicosanoyl-5-hydroxytryptamide; EHT |
| Form | Beige powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| Solubility | May be dissolved in DMSO (30 mg/ml); or ethanol (20 mg/ml, warm) |
| Source | Synthetic |
| Storage |
Eicosanoyl-5-hydroxytryptamide is a natural compound found in coffee that synergizes with caffeine to exert neuroprotective effects. It inhibits PP2A methylesterase, maintaining PP2A activity and reducing alpha-synuclein phosphorylation. In mouse models of Alzheimer’s and Parkinson’s disease, it preserves neuronal integrity, reduces neuroinflammation, and improves cognitive and motor performance, making it a promising candidate for neurodegenerative disease intervention.
Classification: Caution- Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Eicosanoyl-5-hydroxytryptamide (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-615)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Asam K., et al. (2017) PLoS One. 12:e0189413
3. Basurto-Islas G., et al. (2014) Neurobiol. Aging. 35:2701
