Epoxomicin

Epoxomicin is a potent, cell-permeable, and selective inhibitor of the proteasome, originally isolated from an Actinomycetes strain for its antitumor properties. In neuroscience, Epoxomicin is widely used to study the ubiquitin-proteasome system (UPS), a critical pathway for protein degradation and cellular homeostasis in neurons. Dysfunction of the UPS is a hallmark of several neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s disease, where misfolded or aggregated proteins accumulate. Epoxomicin inhibits the chymotrypsin-like, trypsin-like, and PGPH activities of the proteasome, making it a valuable tool for dissecting proteostasis mechanisms. It also indirectly activates autophagy, a compensatory degradation pathway, by blocking UPS function. Additionally, Epoxomicin suppresses NF-κB activation and inflammation, further supporting its use in neuroinflammatory models. Its dual role in modulating protein clearance and inflammatory signaling makes it highly relevant in neurodegenerative disease research.

Classification: Caution. Substance not yet fully tested.

Safety Phrases:

• S22 - Do not breathe dust
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
• S24/25 - Avoid contact with skin and eyes

Epoxomicin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-388)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

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