| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 1-(5-Isoquinolinylsulfonyl) homopiperazine hydrochloride; 5-(1,4-Diazepan-1-ylsulfonyl)isoquinoline |
| Cas No. | |
| Form | Powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (75 mg/ml) or water (100 mg/ml) |
| Source | Synthetic |
| Storage |
Fasudil is a selective Rho-associated protein kinase (ROCK2) inhibitor with additional activity on PRK2 and MSK1, and is gaining traction in neuroscience for its neuroprotective and vasodilatory effects. By modulating cytoskeletal dynamics and reducing neuroinflammation, Fasudil has demonstrated efficacy in models of stroke, spinal cord injury, and Alzheimer’s disease. Its ability to inhibit multiple kinases involved in neuronal signaling and vascular tone positions it as a promising candidate for treating neurovascular and neurodegenerative disorders.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Fasudil (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-371)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Arai M., Nozawa R., et al. (1993) Biochem. Pharmacol. 46(8): 1487-1490.
3. Satoh S., et al. (1996) Br. J. Pharmacol. 118(7): 1592-1606.
4. Sward K., et al. (2000) J. Physiol. 522: 33-49.
