| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one |
| Cas No. | |
| Form | Yellow to orange solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 1 mM in ethanol and to 100 mM in DMSO |
| Source | Synthetic |
| Storage |
GW5074 is a potent and selective inhibitor of c-Raf1 kinase, showing over 100-fold selectivity over other kinases such as CDK1, ERK2, and VEGFR2. In neuroscience, GW5074 is used to study Raf/MEK/ERK signaling in neuronal survival, differentiation, and apoptosis. It has been shown to block low potassium-induced cell death and prevent neurodegeneration. GW5074’s ability to modulate MAPK signaling makes it a key compound for exploring neuroprotective mechanisms and therapeutic targets in neurodegenerative diseases.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
GW5074 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-451)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Lackey K., et al. (2000). Bioorganic Med. Chem. Ltr. 10(3): 223–226.
3. Chang M.S., (2005). Cell Signal. 17(3): 299–310.
