| Field | Specification |
|---|---|
| Target | |
| Alternative names | SERPINH1, HSP47, Heat shock protein 47, Serpin H1, Colligin, Collagen-binding protein, Gp46, Serine protease inhibitor J6, 47 kDa heat shock protein, serine proteinase inhibitor, cysteine proteinase inhibitor, collagen binding protein |
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| Host | |
| Clone | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | Human HSP47, full length |
| Purification | |
| Cellular localization | |
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HSP47, also known as SERPINH1, is a unique member of the serine protease inhibitor (serpin) superfamily that functions as a collagen-specific molecular chaperone. Localized in the endoplasmic reticulum, HSP47 plays a critical role in the intracellular folding, assembly, and secretion of procollagens—particularly type I collagen, a key structural component in tissue repair and remodeling.
Unlike other heat shock proteins, HSP47 binds a single substrate: collagen. This specificity makes it a promising biomarker and therapeutic target in fibrotic diseases, where its expression is markedly elevated around fibrotic lesions. Recent studies suggest that modulating HSP47 activity could support cell-based therapies aimed at halting or reversing fibrosis progression.
In the context of neuroscience, HSP47 is gaining attention for its role in post-injury tissue remodeling. Type I collagen is essential for scar formation and structural integrity following events such as myocardial infarction or central nervous system injury. HSP47 facilitates the proper positioning of collagen-producing cells and the assembly of collagen fibrils—processes that are also relevant in neurodegenerative conditions involving extracellular matrix dysregulation.
Given its substrate specificity and stress-inducible nature, HSP47 represents a novel intersection between fibrosis, wound healing, and neurodegeneration, with potential as a universal marker and therapeutic target in regenerative medicine.
1 µg/ml of SMC-203 was sufficient for detection of HSP47 in 20 µg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-203B — Size: 200 ug: HSP47 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-203B, RRID: AB_2699196)
- SMC-203B-A390 — Size: 200 ug: HSP47 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-203B-A390, RRID: AB_2699197)
- SMC-203B-A488 — Size: 200 ug: HSP47 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-203B-A488, RRID: AB_2699198)
- SMC-203B-A594 — Size: 200 ug: HSP47 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-203B-A594, RRID: AB_2699200)
- SMC-203B-APC — Size: 200 ug: HSP47 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-203B-APC, RRID: AB_2699206)
- SMC-203B-BI — Size: 200 ug: HSP47 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-203B-BI, RRID: AB_2699207)
- SMC-203B-FITC — Size: 200 ug: HSP47 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-203B-FITC, RRID: AB_2699208)
- SMC-203B-HRP — Size: 200 ug: HSP47 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-203B-HRP, RRID: AB_2699209)
- SMC-203B-PCP — Size: 200 ug: HSP47 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-203B-PCP, RRID: AB_2699211)
- SMC-203B-RPE — Size: 200 ug: HSP47 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-203B-RPE, RRID: AB_2699212)
- SMC-203S — Size: 12 ug: HSP47 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-203S, RRID: AB_2699196)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Taguchi T., et al. (2011) Acta Histochem Cytochem. 44(2):35-41.
3. Nong Z., et al. (2011) Am J Pathol. 197(5): 2189-96.
