| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Thyroglobulin, TGN, AITD3, TG. |
| Cellular Localization | |
| Form | Sterile Filtered Off-White lyophilized (freeze-dried) powder. |
| Formulation | |
| Product Type | |
| Protein Size | |
| Purity | |
| Solubility | Use phosphate buffer, pH>7.0 containing 0.15M NaCl is recommended. |
| Source | Human thyroid glands. |
| Species | |
| Storage | |
| Target |
Human Thyroglobulin is supplied as a recombinant protein for in vitro research use.
Background
Thyroglobulin (TG) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. TG is a large globular dimeric glycoprotein with a total molecular weight of 660 kDa, which occupies a key precursor role in the biosynthesis of the thyroid hormones. Approximately 75% of the total protein content of the thyroid follicle consists of TG. The thyroid gland uses the Thyroglobulin in order to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is produced by the thyroid epithelial cells (thyrocytes) which form spherical follicles. Thyroglobulin is subsequently secreted and stored in the follicular lumen. Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against Thyroglobulin. Tg-specific antibodies help in the diagnosis of the above diseases, however they also may be present in apparently healthy euthyroid individuals. Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer, and the may also be elevated in cases of Graves' disease.
Product format
Provided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.
Activity & assay information
- Human Virus Test: Starting material tested and certified negative for HIV I & II antibodies, Hepatitis B surface antigen, Hepatitis C antibodies, Syphilis and HIV-1/HBV/HCV NAT.
What is the purity of Human Thyroglobulin (Human)?
What buffer / formulation is this protein supplied in?
How should Human Thyroglobulin (Human) be stored?
Is this protein approved for clinical or in vitro diagnostic use?
Can I request a custom size, tag variant, or formulation?
Can’t Find What You’re Looking For? We can help you source the best match or customize a recombinant protein solution for your study. Options may include species (human/mouse/rat), protein region/domain (full-length vs fragment), tag or label (His/GST/FLAG/biotin/fluorescent), expression system (E. coli/HEK293/insect), purity grade, formulation (buffer, carrier-free, glycerol-free), activity/functional validation (binding or enzymatic assays), endotoxin level (low-endotoxin for cell-based work), mutants/variants (point mutations, isoforms), and bulk or custom packaging. Click Talk to a Scientist to submit a request form, email us at support@biohippo.com, or explore our Research Services for additional support. Our team will be in contact with you shortly.
