| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human IGF1R recombinant protein (Position: Q44-R960) was used as the immunogen for the IGF1R antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
IGF1R Antibody / Insulin-like growth factor 1 receptor is a anti-IGF1R Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.
Key elements and design rationale
- Target: IGF1R
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, ELISA
Biological background
Insulin-like growth factor 1 receptor is synthesized as a single-chain precursor that is cleaved into alpha and beta subunits, forming a disulfide-linked heterotetramer. The extracellular alpha subunits bind ligand, while the transmembrane beta subunits contain intrinsic tyrosine kinase domains responsible for signal transduction. The IGF1R antibody allows detection of both full-length and processed receptor forms, supporting detailed analysis of receptor biosynthesis and activation states.
IGF1R signaling is essential for embryonic growth, tissue regeneration, and metabolic control. Activation of the receptor stimulates glucose uptake, protein synthesis, and cell survival pathways, maintaining anabolic balance. Dysregulation of Insulin-like growth factor 1 receptor has been linked to cancer, diabetes, and aging-related pathologies. The IGF1R antibody provides a valuable tool for monitoring these changes and understanding how altered receptor signaling drives disease progression. In cancer research, IGF1R overexpression promotes tumor cell proliferation, invasion, and resistance to apoptosis, making it a key target for therapeutic intervention.
In developmental and metabolic studies, the IGF1R antibody helps characterize how ligand-receptor interactions influence growth hormone signaling and nutrient sensing. Immunohistochemistry and immunofluorescence using this antibody reveal receptor localization at the plasma membrane and endosomal compartments, reflecting active signaling dynamics. In addition, phosphorylation-specific variants of the IGF1R antibody can distinguish active receptor states, complementing this general reagent for total protein analysis.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
