| Field | Specification |
|---|---|
| Mfr No | |
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| Host | |
| Immunogen | A synthesized peptide derived from human IL15 was used as the immunogen for the IL15 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
IL15 Antibody / Interleukin 15 is a anti-IL15 Rabbit antibody Recombinant Rabbit Monoclonal clone 31I07 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.
Key elements and design rationale
- Target: IL15
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 31I07, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
IL15 antibody is widely used in immunology, cancer immunotherapy, and infectious disease research. IL15 stimulates proliferation and cytotoxicity of natural killer and CD8 T cells, making it a key cytokine in immune defense. In cancer research, IL15 is studied for its ability to boost antitumor immune responses, and recombinant IL15 is under evaluation in clinical trials as an immunotherapeutic agent. By detecting IL15 expression, researchers can monitor immune activity and evaluate therapeutic strategies.
The antibody is suitable for western blotting, immunohistochemistry, immunofluorescence, flow cytometry, and ELISA. In western blot assays, IL15 antibody identifies protein bands corresponding to the cytokine. Immunohistochemistry localizes IL15 expression within tissues, while immunofluorescence demonstrates cytokine production in immune cell subsets. Flow cytometry enables quantitative detection of IL15 in activated lymphocytes, and ELISA applications support measurement of secreted IL15 in serum or culture media.
IL15 plays roles in autoimmune disease, chronic inflammation, and transplant rejection. Elevated levels contribute to pathological immune activation in conditions such as rheumatoid arthritis, psoriasis, and celiac disease. Conversely, inadequate IL15 signaling impairs immune defense against viral infections. By applying IL15 antibody, researchers can investigate both protective and pathogenic functions of this cytokine.
In addition to its role in adaptive immunity, IL15 regulates innate lymphoid cell function and promotes tissue specific immune surveillance. It is particularly important in mucosal immunity, where it supports barrier protection against pathogens. IL15 antibody therefore provides a versatile tool for basic and translational immunology.
IL15 antibody provided by
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
