| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A recombinant protein fragment specific the the IDH R132H Mutant was used as the immunogen for the Isocitrate Dehydrogenase R132H Mutant antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
Isocitrate Dehydrogenase R132H Mutant Antibody is an antibody targeting Isocitrate. Host: Rabbit. Monoclonal. Clone: IDH1/7277R. Format: Purified. Applications: IHC-P.
Key elements and design rationale
- Target: Isocitrate.
- Immunogen: A recombinant protein fragment specific the the IDH R132H Mutant was used as the immunogen for the Isocitrate Dehydroge….
- Species reactivity: Human.
- Localization: Cytoplasm, nucleus.
- Conjugate: Unconjugated (no label listed).
Biological background (from provided description)
IDH1 R132H antibody binds to IDH1-mutated protein, but does not bind the wild-type IDH1 protein. IDH1 R132H point mutations are frequently seen in World Health Organization grade II and III gliomas and are believed to constitute an early step in tumorigenesis.
Common research applications
- IHC: tissue distribution assessment; interpret with matched controls.
Notes for experimental interpretation
- Account for isoforms, paralogs, and post-translational modifications when interpreting signal.
- Support specificity with biological controls (e.g., KO/KD where available) and technical controls (e.g., secondary-only/isotype).
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
