| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2-{4-[(4-Nitrobenzyl)oxy]phenyl}ethyl carbamimidothioate methanesulfonate (1:1) |
| Cas No. | |
| Form | White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Storage |
KB-R7943 mesylate is a potent and selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger, a key regulator of intracellular calcium homeostasis. In neuroscience, it is used to study calcium dynamics in neurons, especially under pathological conditions such as ischemia and excitotoxicity. By inhibiting calcium influx via the exchanger, KB-R7943 may reduce neuronal injury and has been explored for its neuroprotective potential in stroke and neurodegenerative disease models.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
KB-R7943 mesylate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-312)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Schroder U.H., Breder J, Sabelhaus C.F., Reymann K.G. (1999) Neuropharm. 38(2): 319-321.
3. Watano T., Harada Y., Harada K., Nishimura N. (1999) Br J Pharmacol. 127(8): 1846-1850.
