ML133 HCl

ML133 HCl is a selective inhibitor of Kir2 inwardly rectifying potassium channels. In neuroscience, it has been shown to attenuate microglial proliferation and neuropathic pain behaviors following nerve injury. ML133 also inhibits microglial priming and improves neuronal survival in traumatic brain injury models, positioning Kir2.1 channels as novel therapeutic targets for neuroprotection and inflammation control in CNS disorders.

Classification: Danger. Hazard Statements: H302 - H315 - H318 - H335 - H400

Precautionary Statements:

P273 - P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310

ML133 HCl (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-617)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

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