| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol, 7-[Anilino(phenyl)methyl]-2-methylquinolin-8-ol |
| Cas No. | |
| Form | White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 25 mg/ml DMSO |
| Source | Synthetic |
| Storage |
NSC-66811 is a novel small-molecule inhibitor that disrupts the MDM2-p53 interaction, a key regulatory axis in cell cycle control and apoptosis. By mimicking three critical p53 residues, NSC-66811 binds to MDM2 with high affinity (Ki = 120 nM), preventing MDM2-mediated degradation of p53. This leads to stabilization and activation of p53, promoting transcription of downstream genes involved in cell cycle arrest and apoptosis. While primarily studied in oncology, the p53 pathway is increasingly recognized for its role in neurodegenerative diseases, including Alzheimer's and Parkinson's, where dysregulated apoptosis and impaired DNA repair contribute to neuronal loss. NSC-66811 may offer a mechanistic tool to explore p53-mediated neuroprotection and cellular stress responses in neural models.
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
NSC-66811 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-338)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
