PAC-1

PAC-1 is a small molecule that directly activates procaspase-3 by chelating inhibitory zinc ions, facilitating its autoactivation into caspase-3. While primarily studied in oncology for its pro-apoptotic effects, PAC-1 is also used in neuroscience to investigate caspase-mediated neuronal apoptosis. It serves as a tool for exploring programmed cell death pathways in neurodegenerative diseases and for evaluating neuroprotective interventions that target apoptotic signaling.

GHS Classifcation:

GHSO9 Hazardous to the aquatic environment, Acute hazard, category1, Chronic hazard, categories 1,2 Hazard statement(s): H400

PAC-1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-569)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).