| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059 |
| Cas No. | |
| Form | Pale yellow solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (6mg/mL) |
| Source | Synthetic |
| Storage |
PD98059 is a potent, selective, and reversible inhibitor of MEK1, a kinase upstream of ERK in the MAPK signaling cascade. It binds to the inactive form of MEK1, preventing its activation and subsequent phosphorylation of ERK. In neurodegenerative disease research, PD98059 is used to study the role of MAPK/ERK signaling in neuronal survival, synaptic plasticity, and memory. It is also employed to investigate the impact of ERK inhibition on neuroinflammation and oxidative stress, making it a valuable tool in models of Alzheimer’s and Parkinson’s disease.
Classification: Acute toxicity, Oral (Category 3), H301
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 Toxic if swallowed.
Precautionary statements:
- P264 Wash skin thoroughly after handling.
- P270 Do not eat, drink or smoke when using this product.
- P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
- P321 Specific treatment (see supplemental first aid instructions on this label).
- P330 Rinse mouth.
- P405 Store locked up.
- P501 Dispose of contents/ container to an approved waste disposal plant.
PD98059 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-466)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Qi X., et al. (2004) Pro. Nat. Acad. Sci. USA. 101(16): 6027–6032.
3. Dudley D.T., Pang L., Decker S.J., Bridges A.J., & Saltiel A.R. (1995) Pro. Nat. Acad. Sci. USA. 92(17): 7686–7689.
