| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human Phospho-Tau (S202) was used as the immunogen for the Phospho-Tau (Ser202) antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
Phospho-Tau (Ser202) Antibody / MAPT is a anti-MAPT (phospho-Ser202) Rabbit antibody Recombinant Rabbit Monoclonal clone 31M22 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: MAPT (phospho site: Ser202)
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 31M22, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
Tau normally binds and stabilizes microtubules in axons, promoting neuronal structure and intracellular transport. Research using Phospho-Tau (Ser202) antibody has shown that phosphorylation at Ser202 reduces Tau binding to microtubules, leading to destabilization and cytoskeletal disorganization. This modification is an early hallmark of pathological Tau in Alzheimer disease.
Studies with Phospho-Tau (Ser202) antibody have revealed that hyperphosphorylation at Ser202 and neighboring residues contributes to Tau aggregation into neurofibrillary tangles. These aggregates impair neuronal function and survival, driving neurodegeneration. Detection of Ser202 phosphorylation therefore provides an important marker for disease progression in tauopathies.
In Alzheimer disease, Phospho-Tau (Ser202) antibody has demonstrated strong immunoreactivity in affected brain regions such as the hippocampus and cortex. This phosphorylation is mediated by kinases including GSK3 beta and CDK5, linking Tau pathology to signaling pathways dysregulated in disease. Monitoring Ser202 phosphorylation offers insight into how signaling cascades contribute to neuronal dysfunction.
Beyond Alzheimer disease, Tau phosphorylation at Ser202 is implicated in other neurodegenerative conditions such as progressive supranuclear palsy, corticobasal degeneration, and frontotemporal dementia. Research using Phospho-Tau (Ser202) antibody has shown that this site is consistently phosphorylated across tauopathies, making it a reliable disease marker.
Phospho-Tau (Ser202) antibody is widely used in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry highlights phosphorylated Tau aggregates in brain tissue, western blotting distinguishes pathological from normal isoforms, and immunofluorescence demonstrates subcellular accumulation in neurons. These approaches make the antibody essential for neurodegeneration research.
By supplying validated Phospho-Tau (Ser202) antibody reagents,
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Quantifying post-translational regulation (including phosphorylation) alongside total protein levels.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Phospho-site readouts are condition-dependent and are often compared to total target levels when available.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
