Picropodophyllotoxin

Picropodophyllotoxin is an inhibitor of the insulin-like growth factor 1 receptor (IGF1R), blocking its autophosphorylation and downstream signaling. In neuroscience, IGF1R signaling is associated with neuronal growth, survival, and metabolism. Picropodophyllotoxin is used to explore the role of IGF1R in neurodegenerative diseases, particularly in relation to cell cycle regulation, apoptosis, and synaptic maintenance. Its ability to modulate pAKT and pERK1/2 pathways makes it a useful compound for studying neuroprotective and neurotoxic mechanisms in the brain.

Classification: Acute toxicity, Oral (Category 3), H301

Acute toxicity, Dermal (Category 4), H312

Skin irritation (Category 2), H315

Eye irritation (Category 2A), H319

Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H301 Toxic if swallowed.
• H312 Harmful in contact with skin.
• H315 Causes skin irritation.
• H319 Causes serious eye irritation.
• H335 May cause respiratory irritation.

Precautionary statements:

• P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
• P264 Wash skin thoroughly after handling.
• P270 Do not eat, drink or smoke when using this product.
• P271 Use only outdoors or in a well-ventilated area
• P280 Wear protective gloves/ eye protection/ face protection.
• P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician.
• P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
• P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
• P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
• P322 Specific measures (see supplemental first aid instructions on this label).
• P330 Rinse mouth.
• P332 + P313 If skin irritation occurs: Get medical advice/ attention.
• P337 + P313 If eye irritation persists: Get medical advice/ attention.
• P362 Take off contaminated clothing and wash before reuse.
• P403 + P233 Store in a well - ventilated place. Keep container tightly closed.
• P405 Store locked up.
• P501 Dispose of contents/ container to an approved waste disposal plant.

Picropodophyllotoxin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-467)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

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