| Field | Specification |
|---|---|
| Alternative names | N-sec-Butyl-1-(2-chlorophenyl)-N-methyl-3-isoquinolinecarboxamide |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C21H21CIN2O |
| Purity | |
| Bioactivity | Inducer |
| Activity | |
| Solubility | Soluble to 75 mM in ethanol and to 100 mM in DMSO |
| SMILES | |
| InChIKey | |
| Form | White Crystals |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
PK-11195 is an isoquinoline carboxamide that selectively binds to the translocator protein (TSPO), formerly known as the peripheral benzodiazepine receptor. It is widely used in neuroimaging to detect neuroinflammation via PET scans, particularly in conditions such as Alzheimer's disease, multiple sclerosis, and traumatic brain injury. PK-11195 serves as a biomarker for activated microglia, aiding in the assessment of neuroinflammatory states.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
- R20/21/22- Harmful by inhalation, in contact with skin and if swallowed
- R68- Possible risk of irreversible effects
PK-11195 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-224)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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2. Buck J.R., et al. (2011) J Nucl Med. 52(1): 107-114.
