PK-11195

PK-11195 is an isoquinoline carboxamide that selectively binds to the translocator protein (TSPO), formerly known as the peripheral benzodiazepine receptor. It is widely used in neuroimaging to detect neuroinflammation via PET scans, particularly in conditions such as Alzheimer's disease, multiple sclerosis, and traumatic brain injury. PK-11195 serves as a biomarker for activated microglia, aiding in the assessment of neuroinflammatory states.

Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.

Safety Phrases:

• S22 - Do not breathe dust
• S24/25 - Avoid contact with skin and eyes
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Risk Phrases:

• R20/21/22- Harmful by inhalation, in contact with skin and if swallowed
• R68- Possible risk of irreversible effects

PK-11195 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-224)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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