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Compound Overview
(±)17-HDHA (CAS 90780-52-2) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 90780-52-2 |
|---|---|
| Molecular Formula | C22H32O3 |
| Molecular Weight | 344.50 g/mol |
| SMILES | CCC=C/CC(O)C=CC=C/CC=C/CC=C/CC=C/CCC(O)=O |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
(±)17-HDHA is an autoxidation product of docosahexaenoic acid in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA could be produced by enzymatic oxidation of DHA using soybean lipoxygenase (LO) and is the putative product of mammalian 15-LOs. 17(S)-HDHA was shown to be an inhibitor of U-46619 -induced rabbit and rat aortic smooth muscle contraction with IC50 values of 4.9 and 7.2 uM, respectively. (±)17-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Try the following steps: (1) warm the DMSO solvent to 37–50 °C before adding the compound; (2) vortex vigorously for 30 seconds then bath-sonicate for 1–2 minutes; (3) if still undissolved, prepare a more dilute stock. Note that maximum solubility values are reference conditions — actual solubility can vary with temperature, solvent lot, and compound batch. Contact BioHippo support if dissolution problems persist.
For currently available products, batch-specific purity data (HPLC chromatogram, NMR spectrum, and Certificate of Analysis) is accessible via the DataSheet link on the product page. For future or custom synthesis products, purity determination is conducted upon availability and published on the product page. Contact BioHippo for batch-specific CoA requests or custom synthesis enquiries.
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