| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Cas No. | |
| Form | Off-white solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (25mg/mL); or ethanol (3mg/mL, warm) |
| Source | Synthetic |
| Storage |
PP2 is a selective inhibitor of Src-family tyrosine kinases, including Lck, FynT, and Hck. It potently inhibits phosphorylation of focal adhesion kinase (FAK) and displays high selectivity over ZAP-70 and JAK2. In neurodegenerative disease research, PP2 is used to investigate the role of Src kinases in synaptic signaling, neuroinflammation, and blood-brain barrier integrity. Its application extends to models of Alzheimer’s and multiple sclerosis, where Src-mediated pathways influence neuronal survival and immune responses.
Acute Toxicity:
Oral, Category 3
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
H301:
Toxic if swallowed.
P264:
- Wash {hands} thoroughly after handling.
- P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330:
Rinse mouth
PP2 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-470)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Liu Y., et al. (1999). Chem. & Biol. 6(9): 671–678.
