| Field | Specification |
|---|---|
| Target | |
| Alternative names | UNQ;Il22ra;IL22RA2;UNQ5793;PRO19598;PRO19822;Class II cytokine receptor;CRF2 10;CRF2 S1;CRF2-10;CRF2-S1;CRF2X;Cytokine receptor class II member 10;Cytokine receptor class-II member 10;Cytokine receptor family 2 member 10;Cytokine receptor family type 2;Cytokine receptor family type 2 soluble 1;I22R2;IL 22 receptor subunit alpha 2;IL 22BP;IL 22R alpha 2;IL 22RA2;IL-22 receptor subunit alpha-2;IL22BP;IL-22BP;IL22R alpha 2;IL-22RA2;IL-22R-alpha-2;Interleukin 22 binding protein;Interleukin 22 Receptor alpha 2;Interleukin-22 receptor subunit alpha-2;Interleukin-22-binding protein;MGC150509;MGC150510;soluble 1;ZcytoR16 |
| UniProt # | |
| Accession number | |
| Species | |
| Tag | |
| Expression system | |
| Expression region | |
| Molecular weight | |
| Purity | |
| Bioactivity | Not validated for activity |
| Endotoxin level | |
| Formulation | |
| Form | Lyophilized |
| Storage | |
| Shipping | |
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Scientific Background
Interleukin-22 receptor subunit alpha-2 (IL-22RA2); also known as interleukin-22-binding protein (IL-22BP); is a subunit of the receptor for interleukin 22. IL-22BP belongs to the type I I cytokine receptor family and contains 3 fibronectin type-III domains. IL-22BP/IL-22RA2 is expressed in a range of tissues; including those in the digestive; female reproductive; and immune systems. It is expressed in placenta; spleen; breast; skin and lung. It is also detected in intestinal tract; testis; brain; heart and thymus. The dominant cell types expressing IL-22BP/IL-22RA2 were mononuclear cells and epithelium. IL-22BP/IL-22RA2 may play an important role as an IL-22 antagonist in the regulation of inflammatory responses. Interleukin-22 (IL-22) is a member of IL-10 family. It is produced by T cells and induces the production of acute-phase reactants. IL-22 plays important roles in immune response through activation of the STAT 3 signal transduction pathway. Two types of IL-22-binding receptor have been discovered; a membrane-bound receptor and a soluble receptor.
Product Description
Expression System: HEK293
Recombinant human IL-22BP is expressed in HEK293 Cells spanning Met 1-Pro 231, supplied with a C-His-Fc tag. Purity is 90% as determined by reducing SDS-PAGE and the product is provided as a lyophilized preparation.
Protein Specifications
| Expression Host | HEK293 Cells |
|---|---|
| Tag | C-His-Fc |
| Expression Region | Met 1-Pro 231 |
| Calculated MW | 52.8 kDa |
| Observed MW | 80-90 kDa |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin Level | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Lead Time | 2-3 business days |
| Shelf Life | 12 months |
| Accession Number | NP_851826.1 |
| UniProt # | Q969J5 |
| Alternative Names | UNQ;Il22ra;IL22RA2;UNQ5793;PRO19598;PRO19822;Class II cytokine receptor;CRF2 10;CRF2 S1;CRF2-10;CRF2-S1;CRF2X;Cytokine receptor class II member 10;Cytokine receptor class-II member 10;Cytokine receptor family 2 member 10;Cytokine receptor family type 2;Cytokine receptor family type 2 soluble 1;I22R2;IL 22 receptor subunit alpha 2;IL 22BP;IL 22R alpha 2;IL 22RA2;IL-22 receptor subunit alpha-2;IL22BP;IL-22BP;IL22R alpha 2;IL-22RA2;IL-22R-alpha-2;Interleukin 22 binding protein;Interleukin 22 Receptor alpha 2;Interleukin-22 receptor subunit alpha-2;Interleukin-22-binding protein;MGC150509;MGC150510;soluble 1;ZcytoR16 |
Functional Activity
This lot is supplied as a protein reagent without a validated bioactivity specification. It is suitable for binding assays, immunization, and assay development where enzymatic or receptor activity is not required.
Safety & Handling
This product is for research use only (RUO) and is not intended for human or veterinary diagnostic or therapeutic use. Handle using standard laboratory safety practices.
Related Products
Explore additional recombinant proteins and matched antibodies or ELISA kits for IL-22BP research from Elabscience Biotechnology Co Ltd, or contact us for alternative tags and expression formats.
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