| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Proprotein Convertase Subtilisin/Kexin Type 9, NARC1, Subtilisin/Kexin-Like Protease PC9, HCHOLA3, LDLCQ1, NARC-1, FH3, PC9, Convertase Subtilisin/Kexin Type 9 Preproprotein, Hypercholesterolemia, Autosomal Dominant 3, Neural Apoptosis Regulated Convertase 1, Neural Apoptosis-Regulated Convertase 1, Proprotein Convertase 9, EC 3.4.21.111, EC 3.4.21, EC 3.4.21, PCSK9. |
| Cellular Localization | |
| Concentration | |
| Expression System | |
| Form | Filtered colorless solution. |
| Formulation | |
| Product Type | |
| Protein Length | |
| Protein Size | |
| Purity | |
| Source | HEK 293. |
| Species | |
| Storage | |
| Target |
Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 is supplied as a recombinant protein for in vitro research use.
Background
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) belongs to the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking via regulated or constitutive branches of the secretory pathway. PCSK9 protein goes through an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. PCSK9 is expressed in the liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. PCSK has a role in cholesterol and fatty acid metabolism. PCSK9 gene mutations are linked with autosomal dominant familial hypercholesterolemia.
Product format
Provided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.
What is the purity of Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 (Human)?
What buffer / formulation is this protein supplied in?
How should Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 (Human) be stored?
What expression system was used to produce this protein?
Is this protein approved for clinical or in vitro diagnostic use?
Can I request a custom size, tag variant, or formulation?
Can’t Find What You’re Looking For? We can help you source the best match or customize a recombinant protein solution for your study. Options may include species (human/mouse/rat), protein region/domain (full-length vs fragment), tag or label (His/GST/FLAG/biotin/fluorescent), expression system (E. coli/HEK293/insect), purity grade, formulation (buffer, carrier-free, glycerol-free), activity/functional validation (binding or enzymatic assays), endotoxin level (low-endotoxin for cell-based work), mutants/variants (point mutations, isoforms), and bulk or custom packaging. Click Talk to a Scientist to submit a request form, email us at support@biohippo.com, or explore our Research Services for additional support. Our team will be in contact with you shortly.
