| Field | Specification |
|---|---|
| Mfr No | |
| Cas No. | |
| Clonality | |
| Endotoxin Level | |
| Form | Liquid |
| Product Type | |
| Purity | |
| Reconstitution | |
| Species | |
| Storage | |
| Target | |
| UniProt # |
Scientific Background
Glucagon-like peptide 1 receptor (GLP1R) is a ~53 kDa protein. G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1.
Product Description
efsubaglutide alfa (HW328056) is a research-grade recombinant antibody targeting GLP1R. Highlights- Research Grade — For PK/PD studies, assay development, and ADA research.
Protein Specifications
| Host Species | Human |
|---|---|
| Species Reactivity | Human |
| Clonality | Monoclonal |
| Target | GLP1R |
| Purity | >95% purity as determined by SDS-PAGE. |
| Form | Liquid |
| Storage Buffer | 0.01M PBS, pH 7.4. |
| UniProt | P43220 |
| Endotoxin Level | < 10 EU/mg |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
Applications
| Application |
|---|
| ELISA |
| Functional Assay |
| In Vivo Studies |
Safety & Handling
Customization & Add-ons: Can't find the protein you need—or require a custom format for your assay? We can help you source the best match or support custom recombinant protein solutions for diverse research needs, including expression system selection, tag and fusion options (His, Fc, biotin), purification grade options, formulation preferences (buffer selection, carrier-free, lyophilized or liquid), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
1. Underwood, CR. et al. (2010) The Journal of biological chemistry 285, 723-30. PMID: 19861722
2. Lau, J. et al. (2015) Journal of medicinal chemistry 58, 7370-80. PMID: 26308095
3. Hennen, S. et al. (2016) Scientific reports 6, 26236. PMID: 27196125
4. Song, G. et al. (2017) Nature 546, 312-315. PMID: 28514449
5. van Eyll, B. et al. (1994) FEBS letters 348, 7-13. PMID: 7517895
6. Graziano, MP. et al. (1993) Biochemical and biophysical research communications 196, 141-6. PMID: 8216285
7. Thorens, B. et al. (1993) Diabetes 42, 1678-82. PMID: 8405712
