| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-Benzylamino-2-(R)-[(1-ethyl)-2-hydroxyethylamino]-9-isopropylpurine, 2(R)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine |
| Cas No. | |
| Form | White to off-white solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in ethanol (10mg/mL); or DMSO (10mg/mL, warm) |
| Source | Synthetic |
| Storage |
Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs), particularly CDK1/cyclin B, CDK2, and CDK5/p35. In neurodegenerative disease research, Roscovitine is widely used to study CDK5, a kinase implicated in tau phosphorylation, synaptic dysfunction, and neuronal death. It also affects calcium channel gating and promotes neuronal growth, making it a valuable tool for investigating cell cycle re-entry, neuroprotection, and regeneration in models of Alzheimer’s and other neurodegenerative disorders.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Roscovitine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-472)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
