| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Up to 100 mM in 1eq NaOH. Centrifuge all products before reconstitution (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: (2S)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-1,2-oxazol-4-yl]propanoic acid.
- Also known as: CHEMBL5664840
- CAS number: 252930-37-3
- Molecular formula: C11H19N2O7P.
- Purity: >95%
- Concentration: 0.1-500 µM.
- Form: Lyophilized powder.
- Solubility: Up to 100 mM in 1eq NaOH. Centrifuge all products before reconstitution (10000 x g 5 min).
- Reconstitution: Up to 100 mM in 1eq NaOH. Centrifuge all products before reconstitution (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: AMPA/Kainate receptors
- Source: Synthetic
- Activity: An active enantiomer of ATPO, an antagonist of GluR1-4 and a partial agonist of GluR5. (S)-ATPO antagonized AMPA-induced depolarization in the cortical wedge preparation with (IC50 =15 μM)1.
- Alternative names: CHEMBL5664840
Scientific background
ATPO, a phosphono amino acid, is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoic acid (AP7) and the AMPA and GluR5 agonist, (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl) propionic acid (ATPA).(S)-ATPO acts as a potent and selective AMPA and kainate receptor antagonist. ATPO has the ability to competitively reduce peak responses evoked by semi-rapid applications of AMPA1. It antagonizes AMPA-induced depolarization in the cortical wedge preparation with an IC50 value of 15 µM1.AMPA receptors are the principal glutamate receptors that mediate fast excitatory neurotransmission. This function is essential for synaptic plasticity and cellular correlate of learning and memory. Antagonists of AMPA receptors are good drug candidates for potential treatment of several neurological disorders such as epilepsy, stroke and amyotrophic lateral sclerosis (ALS)2,3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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