| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine |
| Cas No. | |
| Form | White to beige powder. |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (50mg/mL); or ethanol (15mg/mL, warm) |
| Source | Synthetic |
| Storage |
Spautin-1 (specific and potent autophagy inhibitor 1) is a small molecule that inhibits autophagy by targeting the deubiquitinating enzymes USP10 and USP13, leading to degradation of the Beclin-1 complex. In neurodegenerative disease research, Spautin-1 is used to study the role of autophagy in neuronal survival and protein aggregation. Dysregulated autophagy is a hallmark of diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, where accumulation of misfolded proteins contributes to neurotoxicity. By inhibiting autophagy, Spautin-1 helps delineate the protective versus detrimental roles of this pathway in neuronal health and degeneration. It is a valuable tool for dissecting autophagy-related mechanisms in the CNS.
Classification: D2B- Toxic Material Causing Other Toxic Effects, Severe eye irritant
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
- H302- Harmful if swallowed.
- H318- Causes serious eye damage.
Precautionary statements:
- P280- Wear protective gloves/ eye protection/ face protection.
- P305 + P351 + P338- IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Spautin-1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-404)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
