Src I1

Src I1 is a potent and competitive dual-site inhibitor of Src family kinases, including Src and Lck, as well as VEGFR2 and c-Fms. In neuroscience, Src I1 is used to study the role of Src kinases in synaptic signaling, neuroinflammation, and neuronal survival. Src signaling is implicated in neurodegenerative diseases such as Alzheimer's and ALS, where it contributes to excitotoxicity and glial activation. Src I1 is cell-permeable and has been shown to induce apoptosis, making it a useful compound for exploring kinase-targeted neuroprotective strategies.

Classification: Acute toxicity, Oral (Category 4), H302

Skin irritation (Category 2), H315

Eye irritation (Category 2A), H319

Specific target organ toxicity -single exposure (Category 3), Respiratory system, H335

Chronic aquatic toxicity (Category 4), H413

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H302
• Harmful if swallowed.
• H315
• Causes skin irritation.
• H319
• Causes serious eye irritation.
• H335
• May cause respiratory irritation.
• H413
• May cause long lasting harmful effec
• ts to aquatic life.

Precautionary statements:

• P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray
• P264 Wash skin thoroughly after handling.
• P270 Do not eat, drink or smoke when using this product.
• P271 Use only outdoors or in a well-ventilated area.
• P273 Avoid release to the environment.
• P280 Wear protective gloves/ eye protection/ face protection.
• P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
• P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
• P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
• P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
• P321 Specific treatment (see supple mental first aid instructions on this label).
• P330 Rinse mouth.
• P332 + P313 If skin irritation occurs: Get medical advice/ attention.
• P337 + P313 If eye irritation persists: Get medical advice/ attention.
• P362 Take off contaminated clothing and wash be fore reuse.
• P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
• P405 Store locked up.
• P501 Dispose of contents/ container to an approved waste disposal plant

Src I1 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-478)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

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