| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, acetate salt |
| Cas No. | |
| Form | Yellow solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (10 mg/ml) |
| Source | Synthetic |
| Storage |
STO 609 is a potent, competitive, and selective inhibitor of Ca²⁺/calmodulin-dependent protein kinase kinase (CaM-KK). It binds to the catalytic domain of CaMKK and inhibits its autophosphorylation. In neurodegenerative disease research, STO 609 is used to investigate calcium signaling pathways involved in neuronal plasticity, metabolism, and survival. CaMKK signaling is implicated in neuroinflammation and neurodegeneration, making STO 609 a valuable tool for dissecting calcium-dependent regulatory mechanisms in the brain. It is cell-permeable and widely used in both in vitro and in vivo models.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
STO 609 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-479)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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2. Levine Y.C., Li G.K., & Michel T. (2007) J. Biol. Chem. 282(28): 20351–20364.
3. Anderson K.A., et al. (2008) Cell Metabolism. 7(5): 377–388.
