| Field | Specification |
|---|---|
| Alternative Names | Next to BRCA1 gene 1 protein;Cell migration-inducing gene 19 protein;Membrane component chromosome 17 surface marker 2;Neighbor of BRCA1 gene 1 protein;Protein 1A1-3B |
| Antigen | |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Conjugate | |
| Formulation | |
| Gene ID | |
| Host | |
| Immunogen | Recombinant Protein of NBR1 |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® NBR1 Mouse Monoclonal Antibody (7C3) is a mouse monoclonal antibody from UcallM Biosciences Inc, raised against NBR1. It has been validated for Immunofluorescence, Immunohistochemistry and reacts with Human, Mouse, Rat.
Validated Applications
| Target | NBR1 |
|---|---|
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 7C3 |
| Conjugate | Unconjugated |
| Reactivity | Human, Mouse, Rat |
| Applications | Immunofluorescence, Immunohistochemistry |
| Purification | Affinity Purified |
| Specificity | The antibody detects endogenous NBR1 protein |
| Molecular Weight | Observed: 120 kDa |
| UniProt / Swiss-Prot | Q14596 (Human) | P97432 (Mouse) | Q501R9 (Rat) |
Recommended dilutions: IF 1:50-200;IHC 1:50-300
Immunogen / Antigen
Recombinant Protein of NBR1
Reactivity Notes
Confirmed cross-reactivity: Human, Mouse, Rat. Confirm suitability for untested species before use.
Scientific Background
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Safety & Handling
This antibody is validated for Immunofluorescence, Immunohistochemistry. Recommended dilutions: IF 1:50-200;IHC 1:50-300
Confirmed reactivity: Human, Mouse, Rat. Other species should be validated by the user.
Conjugate: Unconjugated.
Store as follows: -15°C to -25°C/1 year(Do not lower than -25°C)
Clone 7C3.
Customization & Add-ons: Can't find exactly what you need? Contact us for custom formats, conjugations, bulk quantities, or related products.
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