| Field | Specification |
|---|---|
| Alternative Names | Kbhb |
| Clonality | |
| Conjugate | |
| Formulation | |
| Host | |
| Immunogen | polypeptide |
| Isotype | |
| Molecular Weight | |
| Product Type | |
| Reactivity | |
| Storage | |
| Target |
Product Overview
U-Blot® Pan-β-Hydroxybutyryllysine Rabbit mAb is a recombinant monoclonal antibody raised in Rabbit that specifically recognizes β-Hydroxybutyryllysine (Lysine β-hydroxybutyrylation [Lys(K)]). It is designed for detection and analysis of the Lysine β-hydroxybutyrylation [Lys(K)] post-translational modification across research applications.
Histones are subject to a variety of enzyme-catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitination, etc. β-Hydroxybutyrylation of lysine (Kbhb) is a newly identified histone marker that is enriched in active gene promoters. Histone Kbhb marks are dramatically induced in response to elevated β-hydroxybutyrate levels in cultured cells and in livers from mice subjected to prolonged fasting or streptozotocin-induced diabetic ketoacidosis. Histone β-hydroxybutyrylation represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of β-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.
Validated Applications
| Application | Western Blot, Immunohistochemistry, Immunofluorescence |
|---|---|
| Recommended Dilution | WB 1:1000-2000, IHC-P 1:200-1:1000, ICC/IF 1:100-200 |
| Host | Rabbit |
| Clonality | Recombinant Monoclonal |
| Isotype | IgG |
| Reactivity | Human, Mouse, Rat |
| Conjugate | Unconjugated |
| Purification | Protein A |
| Molecular Weight | Calculated: Multiple | Observed: Multiple |
Immunogen / Antigen
polypeptide
Reactivity Notes
This antibody shows reactivity with Human, Mouse, Rat. It targets the Lysine β-hydroxybutyrylation [Lys(K)] modification and is suitable for Western Blot, Immunohistochemistry, Immunofluorescence.
Safety & Handling
Related Products
Explore other UcallM Biosciences post-translational modification antibodies available through BioHippo.
It is validated for Western Blot, Immunohistochemistry, Immunofluorescence. Recommended dilutions: WB 1:1000-2000, IHC-P 1:200-1:1000, ICC/IF 1:100-200.
Use WB 1:1000-2000, IHC-P 1:200-1:1000, ICC/IF 1:100-200. Optimal dilution should be determined empirically for your sample and detection system.
This is a pan-modification antibody recognizing β-Hydroxybutyryllysine (Lysine β-hydroxybutyrylation [Lys(K)]); reactivity: Human, Mouse, Rat.
The recombinant monoclonal antibody (Rabbit host) was raised against polypeptide.
This product is supplied unconjugated. Contact BioHippo for custom conjugation or format options.
Store at -20°C. Avoid repeated freeze-thaw cycles | Stable for 12 months from date of receipt / reconstitution.
Customization & Add-ons: Can't find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
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