| Field | Specification |
|---|---|
| Target | |
| Alternative names | Sero |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | polypeptide |
| Conjugate | |
| Molecular weight | |
| Purification | |
| Formulation | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Product Overview
U-Blot® Pan-Serotonyl-Glutamine Rabbit pAb is a polyclonal antibody raised in Rabbit that specifically recognizes Serotonyl-Glutamine (Glutamine serotonylation [Gln(Q)]). It is designed for detection and analysis of the Glutamine serotonylation [Gln(Q)] post-translational modification across research applications.
Glutamine Serotonylation is a novel protein post-translational modification mediated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Catalyzed by transglutaminases (TGases), this modification covalently conjugates serotonin to glutamine residues (Q) of target proteins, forming a stable Serotonyl-Glutamine linkage. Serotonylation regulates the function of small GTPases, ion channels, cytoskeletal proteins, and various signaling proteins, and participates in critical physiological processes including cell secretion, contraction, migration, and signal transduction. It is closely associated with neural regulation, blood coagulation, inflammation, and the pathogenesis of multiple diseases, representing an important research area in post-translational modification studies.
Validated Applications
| Application | Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry |
|---|---|
| Recommended Dilution | WB 1:1000, IHC-P 1:100-1:200, ICC/IF 1:100-1:200, FC 1:100-1:200 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Reactivity | Species Independent |
| Conjugate | Unconjugated |
| Purification | Protein A |
| Molecular Weight | Calculated: Multiple | Observed: Multiple |
Immunogen / Antigen
polypeptide
Reactivity Notes
This antibody shows reactivity with Species Independent. It targets the Glutamine serotonylation [Gln(Q)] modification and is suitable for Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry.
Safety & Handling
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It is validated for Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry. Recommended dilutions: WB 1:1000, IHC-P 1:100-1:200, ICC/IF 1:100-1:200, FC 1:100-1:200.
Use WB 1:1000, IHC-P 1:100-1:200, ICC/IF 1:100-1:200, FC 1:100-1:200. Optimal dilution should be determined empirically for your sample and detection system.
This is a pan-modification antibody recognizing Serotonyl-Glutamine (Glutamine serotonylation [Gln(Q)]); reactivity: Species Independent.
The polyclonal antibody (Rabbit host) was raised against polypeptide.
This product is supplied unconjugated. Contact BioHippo for custom conjugation or format options.
Store at -20°C. Avoid repeated freeze-thaw cycles | Stable for 12 months from date of receipt / reconstitution.
Customization & Add-ons: Can't find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
