U0126

U-0126 is a selective and non-competitive inhibitor of MEK1 and MEK2 (IC50 = 72 nM and 58 nM, respectively), key kinases in the MAPK/ERK signaling cascade. This pathway regulates cell proliferation, differentiation, and survival—processes often dysregulated in neurodegenerative diseases. U-0126 is widely used in neuroscience to investigate ERK-dependent mechanisms of synaptic plasticity, memory formation, and neuronal survival. It also inhibits AP-1 transcriptional activity and suppresses the production of inflammatory cytokines and matrix metalloproteinases, linking it to studies on neuroinflammation and glial activation. U-0126’s ability to induce apoptosis under growth factor deprivation conditions further supports its use in modeling neurodegenerative stress responses. Its fluorescence properties in cell culture also make it a useful marker in imaging-based assays.

Classification: Caution: Substance not yet fully tested.

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

U0126 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-380)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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